Kumar Saurabh Singh
Kumar Saurabh Singh
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2024
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MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with …
Kumar Saurabh Singh
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DOI
Effective data visualization strategies in untargeted metabolomics
LC-MS/MS-based untargeted metabolomics is a rapidly developing research field spawning increasing numbers of computational metabolomics …
Kumar Saurabh Singh
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Pairing omics to decode the diversity of plant specialized metabolism
Plants have evolved complex bouquets of specialized natural products that are utilized in medicine, agriculture, and industry. …
Kumar Saurabh Singh
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Bulk segregant mapping and transcriptome analyses reveal the molecular mechanisms of spinetoram resistance in Spodoptera frugiperda
The evolution of resistance to insecticides poses a significant threat to pest management programs. Understanding the molecular …
Kumar Saurabh Singh
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Overexpression of the UDP-glycosyltransferase UGT34A23 confers resistance to the diamide insecticide chlorantraniliprole in the tomato leafminer, Tuta absoluta
The tomato leafminer, Tuta absoluta, is an invasive crop pest that has evolved resistance to many of the insecticides used for its …
Kumar Saurabh Singh
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A chromosome-scale genome assembly of the pollen beetle, Brassicogethes aeneus, provides insight into cytochrome P450-mediated pyrethroid resistance
The pollen beetle, Brassicogethes aeneus, is an economically important pest of oilseed rape (Brassica napus) throughout Europe. The …
Kumar Saurabh Singh
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Differential regulation of the Tor gene homolog drives the red/green pigmentation phenotype in the aphid Myzus persicae
In some aphid species, intraspecific variation in body colour is caused by differential carotenoid content whilst green aphids contain …
Kumar Saurabh Singh
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The genome sequence of the Neotropical brown stink bug, Euschistus heros provides insights into population structure, demographic history and signatures of adaptation
The Neotropical brown stink bug, Euschistus heros, is a major pest of soybean in South America. The importance of E. heros as a pest …
Kumar Saurabh Singh
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MIBiG 3.0 a community-driven effort to annotate experimentally validated biosynthetic gene clusters
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product …
Kumar Saurabh Singh
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Draft Genome Sequences of the Vibrio parahaemolyticus Strains VHT1 and VHT2, Pasteurization-Resistant Isolates from Environmental Seafood
Two pasteurization-resistant strains, VHT1 and VHT2, of environmental, viable but nonculturable, pathogenic Vibrio parahaemolyticus …
Kumar Saurabh Singh
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Integrative omics approaches for biosynthetic pathway discovery in plants
With the emergence of large amounts of omics data, computational approaches for the identification of plant natural product …
Kumar Saurabh Singh
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Genome assembly of Danaus chrysippus and comparison with the Monarch Danaus plexippus
Milkweed butterflies in the genus Danaus are studied in a diverse range of research fields including the neurobiology of migration, …
Kumar Saurabh Singh
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Molecular innovations underlying resistance to nicotine and neonicotinoids in the aphid Myzus persicae
The green peach aphid, Myzus persicae, is a globally distributed highly damaging crop pest. This species has demonstrated an …
Kumar Saurabh Singh
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DOI
Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae
The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural …
Kumar Saurabh Singh
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DOI
The genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont from plant chemical defenses
Host shifts can lead to ecological speciation and the emergence of new pests and pathogens. However, the mutational events that …
Kumar Saurabh Singh
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De Novo Genome Assembly of the Meadow Brown Butterfly, Maniola jurtina
Meadow brown butterflies (Maniola jurtina) on the Isles of Scilly represent an ideal model in which to dissect the links between …
Kumar Saurabh Singh
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Whole-chromosome hitchhiking driven by a male-killing endosymbiont
Neo-sex chromosomes are found in many taxa, but the forces driving their emergence and spread are poorly understood. The …
Kumar Saurabh Singh
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Host plant adaptation in the polyphagous whitefly, Trialeurodes vaporariorum, is associated with transcriptional plasticity and altered sensitivity to insecticides
The glasshouse whitefly, Trialeurodes vaporariorum, is a damaging crop pest and an invasive generalist capable of feeding on a broad …
Kumar Saurabh Singh
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DOI
The leafcutter bee, Megachile rotundata, is more sensitive to N-cyanoamidine neonicotinoid and butenolide insecticides than other managed bees
Recent research has shown that several managed bee species have specific P450 enzymes that are preadapted to confer intrinsic tolerance …
Kumar Saurabh Singh
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Phylogenomic analyses and distribution of terpene synthases among Streptomyces
Terpene synthases are widely distributed among microorganisms and have been mainly studied in members of the genus Streptomyces. …
Kumar Saurabh Singh
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Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis
The impact of pesticides on the health of bee pollinators is determined in part by the capacity of bee detoxification systems to …
Kumar Saurabh Singh
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Evolution of Mutator transposable elements across eukaryotic diversity
Mutator-like elements (MULEs) are a significant superfamily of DNA transposons on account of their (i) great transpositional activity …
Kumar Saurabh Singh
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DOI
Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides
The impact of neonicotinoid insecticides on the health of bee pollinators is a topic of intensive research and considerable current …
Kumar Saurabh Singh
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DOI
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper
Gene duplication is a major source of genetic variation that has been shown to underpin the evolution of a wide range of adaptive …
Kumar Saurabh Singh
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DOI
Extension of Partial Gene Transcripts by Iterative Mapping of RNA-Seq Raw Reads
Many non-model organisms lack reference genomes and the sequencing and de novo assembly of an organisms transcriptome is an affordable …
Kumar Saurabh Singh
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Use of the synergist piperonyl butoxide can slow the development of alpha‐cypermethrin resistance in the whitefly Bemisia tabaci
The development of insecticide resistance in insect pests of crops is a growing threat to sustainable food production, and strategies …
Kumar Saurabh Singh
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SaDA - From Sampling to Data Analysis—An Extensible Open Source Infrastructure for Rapid, Robust and Automated Management and Analysis of Modern Ecological High-Throughput Microarray Data
One of the most crucial characteristics of day-to-day laboratory information management is the collection, storage and retrieval of …
Kumar Saurabh Singh
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Molecular Tools for the Selective Detection of Nine Diatom Species Biomarkers of Various Water Quality Levels
Our understanding of the composition of diatom communities and their response to environmental changes is currently limited by …
Kumar Saurabh Singh
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Molecular Detection of a Potentially Toxic Diatom Species
A few diatom species produce toxins that affect human and animal health. Among these, members of the Pseudo-nitzschia genus were the …
Kumar Saurabh Singh
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Draft Genome Sequence of the Extremely Halophilic Phototrophic Purple Sulfur Bacterium Halorhodospira halochloris
Halorhodospira halochloris is an extremely halophilic bacterium isolated from hypersaline Wadi Nantrun lakes in Egypt. Here we report …
Kumar Saurabh Singh
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